Robo2 - roundabout guidance receptor 2

Predicted to enable identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and positive regulation of Notch signaling pathway involved in heart induction. Acts upstream of or within axon guidance and metanephros development. Located in axolemma. Is expressed in several structures, including embryo mesenchyme; foot; jaw; nervous system; and urinary system. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2). [provided by Alliance of Genome Resources, Apr 2022]