Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Acts upstream of or within nervous system development. Located in postsynaptic cytosol; postsynaptic density; and presynaptic cytosol. Is active in glutamatergic synapse. Is expressed in nervous system. Orthologous to human FBXO45 (F-box protein 45). [provided by Alliance of Genome Resources, Apr 2022]