Npc1 - NPC intracellular cholesterol transporter 1

Predicted to enable cholesterol binding activity. Involved in negative regulation of cell death and response to cadmium ion. Predicted to be located in several cellular components, including membrane raft; nuclear envelope; and perinuclear region of cytoplasm. Predicted to be integral component of lysosomal membrane and integral component of plasma membrane. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular cholesterol transporter 1). [provided by Alliance of Genome Resources, Apr 2022]