Enables syntaxin-1 binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-protein transferase activity. Involved in positive regulation of cellular protein metabolic process; response to peptide hormone; and ubiquitin-dependent protein catabolic process. Located in axon terminus and cytosol. Is extrinsic component of membrane. Part of protein-containing complex. Biomarker of nephrogenic diabetes insipidus. Orthologous to human RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Apr 2022]