Irak4 - interleukin-1 receptor-associated kinase 4

Enables interleukin-1 receptor binding activity. Acts upstream of or within cytokine-mediated signaling pathway. Predicted to be located in extracellular space. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in central nervous system; dorsal aorta; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]