Fadd - Fas associated via death domain

Enables protease binding activity; receptor serine/threonine kinase binding activity; and tumor necrosis factor receptor superfamily binding activity. Involved in kidney development; regulation of necroptotic process; and response to alkaloid. Located in several cellular components, including cell body; membrane raft; and neuron projection. Part of CD95 death-inducing signaling complex. Used to study morphine dependence and prostatic hypertrophy. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; brain glioma; mental depression; middle cerebral artery infarction; and obesity. Human ortholog(s) of this gene implicated in leukemia. Orthologous to human FADD (Fas associated via death domain). [provided by Alliance of Genome Resources, Apr 2022]