Homer2 - homer scaffolding protein 2

Enables actin binding activity and synaptic receptor adaptor activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including behavioral response to cocaine; calcium-mediated signaling using intracellular calcium source; and chemical homeostasis within a tissue. Located in several cellular components, including apical part of cell; postsynaptic density; and stereocilium tip. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Apr 2022]