Cul3 - cullin 3

Enables cyclin binding activity and identical protein binding activity. Involved in embryonic cleavage; integrin-mediated signaling pathway; and stem cell division. Acts upstream of or within with a positive effect on protein polyubiquitination. Acts upstream of or within several processes, including embryonic morphogenesis; fibroblast apoptotic process; and liver morphogenesis. Located in Golgi apparatus and nucleus. Is expressed in several structures, including extraembryonic component; gonad; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Apr 2022]