Creb3l1 - cAMP responsive element binding protein 3-like 1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and chromatin binding activity. Involved in several processes, including extracellular matrix constituent secretion; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Acts upstream of or within regulation of ossification. Located in endoplasmic reticulum and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to human CREB3L1 (cAMP responsive element binding protein 3 like 1). [provided by Alliance of Genome Resources, Apr 2022]