Mapk3 - mitogen-activated protein kinase 3

Enables MAP kinase activity; MAP kinase kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including negative regulation of apolipoprotein binding activity; regulation of DNA-binding transcription factor activity; and sensory perception of pain. Acts upstream of or within several processes, including Bergmann glial cell differentiation; ERK1 and ERK2 cascade; and animal organ development. Located in cytosol; nucleus; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]