Mapk1 - mitogen-activated protein kinase 1

Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein kinase activity. Involved in peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and response to nicotine. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and cellular response to cytokine stimulus. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]