Map3k7 - mitogen-activated protein kinase kinase kinase 7

Enables enzyme activator activity; protein kinase activity; and receptor tyrosine kinase binding activity. Involved in several processes, including JNK cascade; anoikis; and negative regulation of necroptotic process. Acts upstream of or within several processes, including intracellular signal transduction; regulation of signal transduction; and tube morphogenesis. Located in postsynaptic density. Is expressed in several structures, including central nervous system; gut; metanephros; reproductive system; and respiratory system. Used to study Wolff-Parkinson-White syndrome. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]