Map3k5 - mitogen-activated protein kinase kinase kinase 5

Enables MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JNK cascade; and positive regulation of cell death. Acts upstream of or within several processes, including cellular response to reactive nitrogen species; intracellular signal transduction; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm. Predicted to be part of IRE1-TRAF2-ASK1 complex and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]