Hsf4 - heat shock transcription factor 4

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within several processes, including histone H3-K9 demethylation; regulation of transcription by RNA polymerase II; and visual perception. Predicted to be located in nuclear speck. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including brain; lens; respiratory system; submandibular gland; and urinary system. Used to study cataract 5 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 5 multiple types. Orthologous to human HSF4 (heat shock transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]