Cacna1b - calcium voltage-gated channel subunit alpha1 B

Enables high voltage-gated calcium channel activity; protein phosphatase 2A binding activity; and voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including positive regulation of neurotransmitter secretion; response to ethanol; and response to testosterone. Located in several cellular components, including axon terminus; dendritic shaft; and neuronal cell body. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Apr 2022]