Enables signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; endodermal cell differentiation; and stress fiber assembly. Predicted to be located in cell leading edge; cell surface; and focal adhesion. Predicted to be integral component of synaptic membrane. Predicted to be part of integrin alphav-beta5 complex. Predicted to be active in glutamatergic synapse. Orthologous to human ITGB5 (integrin subunit beta 5). [provided by Alliance of Genome Resources, Apr 2022]