Alas2 - 5'-aminolevulinate synthase 2

Enables 5-aminolevulinate synthase activity and coenzyme A binding activity. Involved in several processes, including gland development; response to benzene; and response to lead ion. Located in mitochondrion. Biomarker of anemia; bilirubin metabolic disorder; and hemolytic anemia. Human ortholog(s) of this gene implicated in cutaneous porphyria; erythropoietic protoporphyria; hemochromatosis; sideroblastic anemia; and sideroblastic anemia 1. Orthologous to human ALAS2 (5'-aminolevulinate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]