Enables estrogen receptor binding activity. Involved in several processes, including estrous cycle; liver regeneration; and response to dexamethasone. Located in nucleus. Biomarker of several diseases, including brain ischemia (multiple); mucositis; obstructive jaundice; osteoporosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Apr 2022]