Slc11a2 - solute carrier family 11 member 2

Enables lead ion transmembrane transporter activity; transition metal ion binding activity; and transition metal ion transmembrane transporter activity. Involved in several processes, including cellular response to tumor necrosis factor; response to lead ion; and transition metal ion transport. Located in apical part of cell; late endosome membrane; and lysosomal membrane. Is integral component of membrane. Used to study Parkinsonism; hypochromic anemia; and pneumonia. Biomarker of brain ischemia; duodenal ulcer; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Apr 2022]