Itpr3 - inositol 1,4,5-trisphosphate receptor, type 3

Enables several functions, including alcohol binding activity; identical protein binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in G protein-coupled receptor signaling pathway; cellular response to cAMP; and positive regulation of cytosolic calcium ion concentration. Located in several cellular components, including brush border; neuronal cell body; and nuclear outer membrane. Is active in presynapse. Is integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Apr 2022]