Pparg - peroxisome proliferator-activated receptor gamma

Enables several functions, including DNA-binding transcription factor activity; estrogen receptor binding activity; and protein phosphatase binding activity. Involved in several processes, including positive regulation of cell differentiation; regulation of cellular macromolecule biosynthetic process; and response to vitamin. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Used to study several diseases, including acute kidney failure; artery disease (multiple); pancreatitis; polycystic kidney disease; and transient cerebral ischemia. Biomarker of several diseases, including alcoholic cardiomyopathy; diabetic encephalopathy; hyperandrogenism; obesity; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma). [provided by Alliance of Genome Resources, Apr 2022]