Nkx2-1 - NK2 homeobox 1

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; TBP-class protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to leptin stimulus; embryonic lung development; and hyperosmotic salinity response. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]