Tnfrsf1a - TNF receptor superfamily member 1A

Enables protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of apoptotic process; and regulation of cytokine production. Located in several cellular components, including cell surface; membrane raft; and mitochondrion. Part of protein-containing complex. Used to study ischemia (multiple); middle cerebral artery infarction; myocardial infarction; uveitis; and visual epilepsy. Biomarker of several diseases, including root resorption; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; acne; allergic bronchopulmonary aspergillosis; autoimmune disease (multiple); and autosomal dominant familial periodic fever. Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A). [provided by Alliance of Genome Resources, Apr 2022]