Ptpn11 - protein tyrosine phosphatase, non-receptor type 11

Enables several functions, including insulin receptor substrate binding activity; phospholipase binding activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide hormone stimulus; and positive regulation of focal adhesion assembly. Located in cytosol; mitochondrion; and plasma membrane raft. Part of protein-containing complex. Used to study glaucoma. Biomarker of glaucoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 1; atrophic gastritis; juvenile myelomonocytic leukemia; and metachondromatosis. Orthologous to human PTPN11 (protein tyrosine phosphatase non-receptor type 11). [provided by Alliance of Genome Resources, Apr 2022]