Crem - cAMP responsive element modulator

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including glucose metabolic process; regulation of circadian rhythm; and retinoic acid receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Biomarker of transient cerebral ischemia. Orthologous to human CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Apr 2022]