Ptk2 - protein tyrosine kinase 2

Enables several functions, including identical protein binding activity; integrin binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular chloride ion homeostasis; positive regulation of cell population proliferation; and regulation of cell migration. Located in several cellular components, including basolateral plasma membrane; focal adhesion; and nuclear lumen. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma; hypertension; and nephritis. Biomarker of hypertension; ischemia; and uremia. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]