Ptprz1 - protein tyrosine phosphatase, receptor type Z1

Enables fibroblast growth factor binding activity and protein tyrosine phosphatase activity. Involved in several processes, including nervous system development; positive regulation of cell migration; and regulation of dendrite development. Located in several cellular components, including lamellipodium; perineuronal net; and ruffle membrane. Is intrinsic component of plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Biomarker of amyotrophic lateral sclerosis; middle cerebral artery infarction; status epilepticus; temporal lobe epilepsy; and visual epilepsy. Orthologous to human PTPRZ1 (protein tyrosine phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Apr 2022]