Parp1 - poly (ADP-ribose) polymerase 1

Enables several functions, including NAD+ ADP-ribosyltransferase activity; R-SMAD binding activity; and estrogen receptor binding activity. Involved in several processes, including positive regulation of signal transduction; regulation of neuron death; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Used to study congestive heart failure; middle cerebral artery infarction; and transient cerebral ischemia. Biomarker of several diseases, including borna disease; cerebrovascular disease (multiple); kidney failure; perinatal necrotizing enterocolitis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including arthritis; bacterial meningitis; neurodegenerative disease (multiple); stomach carcinoma; and type 2 diabetes mellitus. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1). [provided by Alliance of Genome Resources, Apr 2022]