Chrna4 - cholinergic receptor nicotinic alpha 4 subunit

Enables acetylcholine binding activity; acetylcholine-gated cation-selective channel activity; and quaternary ammonium group binding activity. Contributes to heterocyclic compound binding activity. Involved in cholinergic synaptic transmission; regulation of acetylcholine-gated cation channel activity; and response to acetylcholine. Located in dendrite; membrane; and neuronal cell body. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 1 and nicotine dependence. Orthologous to human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit). [provided by Alliance of Genome Resources, Apr 2022]