F3 - coagulation factor III, tissue factor

Enables protease binding activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; positive regulation of smooth muscle cell migration; and response to estradiol. Located in cell surface; cytoplasm; and extracellular space. Biomarker of disseminated intravascular coagulation; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor). [provided by Alliance of Genome Resources, Apr 2022]