Slc34a1 - solute carrier family 34 member 1

Enables PDZ domain binding activity and identical protein binding activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; ion transmembrane transport; and regulation of phosphate transport. Located in several cellular components, including apical plasma membrane; brush border membrane; and membrane raft. Is intrinsic component of plasma membrane. Biomarker of autosomal dominant polycystic kidney disease; chronic kidney disease (multiple); hyperthyroidism; hypophosphatemia; and hypothyroidism. Human ortholog(s) of this gene implicated in several diseases, including Fanconi syndrome (multiple); chronic kidney disease; hereditary hypophosphatemic rickets with hypercalciuria; hypophosphatemic nephrolithiasis/osteoporosis 1; and nephrolithiasis. Orthologous to human SLC34A1 (solute carrier family 34 member 1). [provided by Alliance of Genome Resources, Apr 2022]