Pik3r1 - phosphoinositide-3-kinase regulatory subunit 1

Enables several functions, including 1-phosphatidylinositol-3-kinase regulator activity; calmodulin binding activity; and enzyme binding activity. Contributes to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including regulation of phosphorylation; response to steroid hormone; and transmembrane receptor protein tyrosine kinase signaling pathway. Located in neuron projection; nucleus; and plasma membrane. Part of phosphatidylinositol 3-kinase complex. Used to study hypertension and portal hypertension. Biomarker of hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; astroblastoma; endometrial cancer (multiple); immunodeficiency 36; and type 2 diabetes mellitus. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]