P2rx1 - purinergic receptor P2X 1

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and suramin binding activity. Involved in several processes, including glutamatergic synaptic transmission; neuronal action potential; and regulation of cytosolic calcium ion concentration. Located in membrane raft; neuron projection; and plasma membrane. Part of protein-containing complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic active zone membrane. Orthologous to human P2RX1 (purinergic receptor P2X 1). [provided by Alliance of Genome Resources, Apr 2022]