Kcne1 - potassium voltage-gated channel subfamily E regulatory subunit 1

Enables delayed rectifier potassium channel activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to acidic pH; negative regulation of protein targeting to membrane; and regulation of cation channel activity. Located in Z disc; apical plasma membrane; and endoplasmic reticulum. Part of voltage-gated potassium channel complex. Colocalizes with Golgi apparatus. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in Jervell-Lange Nielsen syndrome; atrial fibrillation; long QT syndrome; and long QT syndrome 5. Orthologous to human KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]