Arrb2 - arrestin, beta 2

Enables several functions, including 14-3-3 protein binding activity; G protein-coupled receptor binding activity; and arrestin family protein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of apoptotic process; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic density. Biomarker of hypertension; portal hypertension; and type 2 diabetes mellitus. Orthologous to human ARRB2 (arrestin beta 2). [provided by Alliance of Genome Resources, Apr 2022]