Anxa1 - annexin A1

Enables several functions, including DNA/DNA annealing activity; double-stranded DNA helicase activity; and phospholipase A2 inhibitor activity. Contributes to single-stranded DNA binding activity and single-stranded RNA binding activity. Involved in several processes, including estrous cycle; gland development; and peptide hormone secretion. Located in several cellular components, including extracellular space; mast cell granule; and mitochondrial membrane. Part of protein-containing complex. Is active in synaptic membrane. Used to study acute kidney failure; brain ischemia; pleurisy; and uveitis. Biomarker of several diseases, including carcinoma (multiple); cerebral infarction; eye disease (multiple); hyperthyroidism; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1). [provided by Alliance of Genome Resources, Apr 2022]