Sod3 - superoxide dismutase 3

Enables superoxide dismutase activity. Involved in blood vessel diameter maintenance; response to copper ion; and response to oxidative stress. Located in several cellular components, including collagen-containing extracellular matrix; extracellular space; and nucleus. Used to study hypertension. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3). [provided by Alliance of Genome Resources, Apr 2022]