Phb1 - prohibitin 1

Predicted to enable several functions, including complement binding activity; histone deacetylase binding activity; and protein C-terminus binding activity. Involved in several processes, including female gonad development; positive regulation of protein kinase B signaling; and positive regulation of smooth muscle cell proliferation. Located in mitochondrial crista and nucleus. Is extrinsic component of mitochondrial outer membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is extrinsic component of presynaptic active zone membrane. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB (prohibitin). [provided by Alliance of Genome Resources, Apr 2022]