Dyrk1a - dual specificity tyrosine phosphorylation regulated kinase 1A

Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in protein phosphorylation and regulation of RNA splicing. Located in nuclear speck. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]