Ghr - growth hormone receptor

Enables SH2 domain binding activity; enzyme binding activity; and growth hormone receptor activity. Involved in several processes, including activation of Janus kinase activity; cellular response to hormone stimulus; and receptor signaling pathway via JAK-STAT. Located in several cellular components, including extracellular space; mitochondrion; and neuronal cell body. Biomarker of congenital hypothyroidism; muscular atrophy; osteopetrosis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]