Akt2 - AKT serine/threonine kinase 2

Enables ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of glucose import; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within cellular response to insulin stimulus and positive regulation of sodium ion transport. Located in several cellular components, including insulin-responsive compartment; mitochondrion; and sarcoplasmic reticulum. Used to study high grade glioma and ischemia. Biomarker of colorectal cancer; hepatocellular carcinoma; hypertension; and obesity. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); hypoinsulinemic hypoglycemia with hemihypertrophy; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]