Pcsk1 - proprotein convertase subtilisin/kexin type 1

Enables endopeptidase activity. Involved in several processes, including nervous system development; protein processing; and response to morphine. Located in several cellular components, including perikaryon; rough endoplasmic reticulum; and trans-Golgi network. Colocalizes with secretory granule. Used to study hyperglycemia and type 2 diabetes mellitus. Biomarker of glucose metabolism disease (multiple); hyperthyroidism; hypothyroidism; islet cell tumor; and visual epilepsy. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Apr 2022]