Syk - spleen associated tyrosine kinase

Enables protein domain specific binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in positive regulation of mast cell degranulation and protein autophosphorylation. Predicted to be located in early phagosome and nucleus. Predicted to be part of B cell receptor complex and T cell receptor complex. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Used to study anti-basement membrane glomerulonephritis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SYK (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]