Pld1 - phospholipase D1

Enables phospholipase D activity. Involved in phospholipid catabolic process; positive regulation of cell migration; and response to peptide hormone. Acts upstream of or within phosphatidic acid biosynthetic process. Located in Golgi cisterna; lamellipodium; and vesicle. Is active in synapse. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to human PLD1 (phospholipase D1). [provided by Alliance of Genome Resources, Apr 2022]