Cyp2e1 - cytochrome P450, family 2, subfamily e, polypeptide 1

Enables Hsp70 protein binding activity and Hsp90 protein binding activity. Involved in several processes, including response to ethanol; response to ozone; and triglyceride metabolic process. Located in Golgi membrane; endoplasmic reticulum membrane; and mitochondrial inner membrane. Is intrinsic component of endoplasmic reticulum membrane. Used to study drug-induced hepatitis. Biomarker of several diseases, including alcohol use disorder; fatty liver disease (multiple); liver disease (multiple); middle cerebral artery infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; fatty liver disease; gastrointestinal system cancer (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Apr 2022]