Th - tyrosine hydroxylase

Enables several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; carboxylic acid metabolic process; and cellular response to nicotine. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and terminal bouton. Used to study Parkinson's disease. Biomarker of several diseases, including brain disease (multiple); hyperprolactinemia; hypoglycemia; polycystic ovary syndrome; and portal hypertension. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]