Htr1b - 5-hydroxytryptamine receptor 1B

Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including modulation of chemical synaptic transmission; regulation of amine transport; and response to cocaine. Located in plasma membrane. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]