Ntrk2 - neurotrophic receptor tyrosine kinase 2

Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor-activated receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including distal axon; perikaryon; and postsynaptic density. Is integral component of plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]