RT1-Ha - RT1 class II, locus Ha

Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of interferon-gamma production. Predicted to be located in cell surface and intracellular membrane-bounded organelle. Predicted to be part of MHC class II protein complex. Human ortholog(s) of this gene implicated in several diseases, including Crohn's disease; asthma (multiple); hepatitis B; liver disease (multiple); and onchocerciasis. Orthologous to human HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1). [provided by Alliance of Genome Resources, Apr 2022]