Insr - insulin receptor

Enables several functions, including enzyme binding activity; insulin binding activity; and insulin receptor substrate binding activity. Involved in several processes, including animal organ development; neuron projection organization; and regulation of glucose metabolic process. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and yolk. Colocalizes with dendrite and neuronal cell body. Used to study chronic kidney disease; diabetic neuropathy; fatty liver disease (multiple); hepatocellular carcinoma; and type 2 diabetes mellitus. Biomarker of several diseases, including diabetes mellitus (multiple); fatty liver disease (multiple); hepatic encephalopathy; hepatocellular carcinoma; and short bowel syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor). [provided by Alliance of Genome Resources, Apr 2022]